Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus.

@article{Kralj2011IdentificationON,
  title={Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus.},
  author={Ana Kralj and Alexander Wetzel and Shohreh Mahmoudian and Thomas Stamminger and Nuska Tschammer and Markus R Heinrich},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 18},
  pages={5446-50}
}
The highly constitutively active G-protein coupled receptor US28 of human cytomegalovirus (HCMV) is an interesting pharmacological target because of its implication on viral dissemination, cardiovascular diseases and tumorigenesis. We found that dihydroisoquinolinone and tetrahydroisoquinoline scaffolds may be promising lead structures for novel US28 allosteric inverse agonists. These scaffolds were rapidly synthesized by radical carboamination reactions followed by non-radical transformations… CONTINUE READING

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