Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator.

  title={Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator.},
  author={Yoshio Takei and Koji Inoue and Maho Ogoshi and Tetsushi Kawahara and Hideo Bannai and Satoru Miyano},
  journal={FEBS letters},
  volume={556 1-3},
We have identified cDNA encoding a new member of the adrenomedullin (AM) family, AM2, for the first time in mammals (mouse, rat and human). The predicted precursor carried mature AM2 in the C-terminus, which had an intramolecular ring formed by an S-S bond and a possibly amidated C-terminus. Phylogenetic analyses clustered AM2 and AM into two distinct but closely related groups. Similarity of exon-intron structure and synteny of neighboring genes showed that mammalian AM2 is an ortholog of… CONTINUE READING
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