Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development.

@article{Kim2007IdentificationON,
  title={Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development.},
  author={H. C. Kim and Myoung Shin Kim and Anne L. Hancock and James C P Harper and Jik Young Park and George Poy and Alan O Perantoni and Margaret C. Cam and Karim Malik and Sean Bong Lee},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 22},
  pages={16278-87}
}
The Wilms' tumor suppressor gene (WT1) encodes a zinc finger transcription factor that is vital during development of several organs including metanephric kidneys. Despite the critical regulatory role of WT1, the pathways and mechanisms by which WT1 orchestrates development remain elusive. To identify WT1 target genes, we performed a genome-wide expression profiling analysis in cells expressing inducible WT1. We identified a number of direct WT1 target genes, including the epidermal growth… CONTINUE READING
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