Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.

@article{Mueller2011IdentificationON,
  title={Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.},
  author={Sandra M Mueller and Mariusz W. Szkudlinski and Joerg Schaarschmidt and Robert G{\"u}nther and R. Paschke and Holger Jaeschke},
  journal={Endocrinology},
  year={2011},
  volume={152 8},
  pages={3268-78}
}
In which ways the binding of the thyroid stimulating hormone to the extracellular domain of its receptor leads to activation of the thyroid-stimulating hormone receptor (TSHR) is currently only incompletely understood. It is known that TSH binding to the TSHR depends on the interaction with the leucine-rich repeat and sulfation at Y385 of the hinge region. Recently it was also shown that electrostatic interactions between positive charges of bovine (b) TSH and the residues E297, E303, and D382… CONTINUE READING