Identification of novel TCDD-regulated genes by microarray analysis.

  title={Identification of novel TCDD-regulated genes by microarray analysis.},
  author={Paul R Hanlon and Wenchao Zheng and Alex Y Ko and Colin R Jefcoate},
  journal={Toxicology and applied pharmacology},
  volume={202 3},
TCDD exposure of multipotential C3H10T1/2 fibroblasts for 72 h altered the expression of over 1000 genes, including coordinated changes across large functionally similar gene clusters. TCDD coordinately induced 23 cell cycle-related genes similar to epidermal growth factor (EGF)-induced levels but without any affect on the major mitogenic signaling pathway (extracellular signal-regulated kinase, ERK). TCDD treatment also decreased glycolytic and ribosomal clusters. Most of these TCDD-induced… CONTINUE READING