Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay

@article{Akiyama2012IdentificationON,
  title={Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay},
  author={Yasuto Akiyama and Masaru Komiyama and Yoji Nakamura and Akira Iizuka and Chie Oshita and Akiko Kume and Masahiro Nogami and Haruo Miyata and Tadashi Ashizawa and Shusuke Yoshikawa and Yoshio Kiyohara and Ken Yamaguchi},
  journal={Cancer Immunology, Immunotherapy},
  year={2012},
  volume={61},
  pages={2311-2319}
}
Many cancer-testis antigen genes have been identified; however, few human leukocyte antigen (HLA)-A24-restricted cytotoxic T cell (CTL) epitope peptides are available for clinical immunotherapy. To solve this problem, novel tools increasing the efficacy and accuracy of CTL epitope detection are needed. In the present study, we utilized a highly active dendritic cell (DC)-culture method and an in silico HLA-A24 peptide-docking simulation assay to identify novel CTL epitopes from MAGE-A6 and MAGE… CONTINUE READING