Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system.

@article{Thaminy2003IdentificationON,
  title={Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system.},
  author={Safia Thaminy and Daniel Auerbach and Anthony Arnoldo and Igor Stagljar},
  journal={Genome research},
  year={2003},
  volume={13 7},
  pages={
          1744-53
        }
}
Analysis of membrane protein interactions is difficult because of the hydrophobic nature of these proteins, which often renders conventional biochemical and genetic assays fruitless. This is a substantial problem because proteins that are integral or associated with membranes represent approximately one-third of all proteins in a typical eukaryotic cell. We have shown previously that the modified split-ubiquitin system can be used as a genetic assay for the in vivo detection of interactions… CONTINUE READING

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