Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays.

@article{Muthukumarasamy2016IdentificationON,
  title={Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays.},
  author={Kalai Mangai Muthukumarasamy and Kishor L Handore and Dipti N Kakade and Madhuri Vikas Shinde and Shashi Ranjan and Naveen Kumar and Seema Sehrawat and Chetana Sachidanandan and D Srinivasa Reddy},
  journal={Organic \& biomolecular chemistry},
  year={2016},
  volume={14 5},
  pages={
          1569-78
        }
}
Noreremophilanes are a rare class of cis-hydrindanes produced by genus Ligularia herbaceous plants which are known to exhibit interesting biological activities. We synthesized cis-hydrindanes based on a naturally occurring noreremophilane scaffold using a Diels-Alder/aldol sequence and screened them for multiple biological activities using high-content zebrafish embryonic development assays. We discovered a noreremophilane that has strong anti-angiogenic effects on the developing zebrafish… Expand
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Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia.
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