Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.

@article{Whitnall2012IdentificationON,
  title={Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.},
  author={Megan Whitnall and Yohan Suryo Rahmanto and Michael L. H. Huang and Federica Saletta and Hiu Chuen Lok and Luc{\'i}a Guti{\'e}rrez and Francisco Jos{\'e} L{\'a}zaro and Adam J Fleming and Tim St Pierre and Marc R Mikhael and Prem Ponka and Des. R. Richardson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 50},
  pages={20590-5}
}
There is no effective treatment for the cardiomyopathy of the most common autosomal recessive ataxia, Friedreich ataxia (FA). This disease is due to decreased expression of the mitochondrial protein, frataxin, which leads to alterations in mitochondrial iron (Fe) metabolism. The identification of potentially toxic mitochondrial Fe deposits in FA suggests Fe… CONTINUE READING