Identification of nonconserved amino acids in the AT1 receptor which comprise a general binding site for biphenylimidazole antagonists.

Abstract

Mutational analysis based on pharmacological differences between mammalian and amphibian angiotensin II receptors (AT receptors) previously led to construction of a mutant receptor that gained > 25000-fold affinity for the biphenylimidazole, Losartan. This variant frog receptor also bound with high affinity other nonpeptides in the biphenylimidazole… (More)

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