Identification of nitric oxide donors by biomimetic HTS application.

  title={Identification of nitric oxide donors by biomimetic HTS application.},
  author={Gy{\"o}rgy T Balogh and Bal{\'a}zs Dalmadi and Attila Bielik and Gy{\"o}rgy M. Keser{\"u}},
  journal={Combinatorial chemistry & high throughput screening},
  volume={8 4},
Metalloporphyrin catalyzed biomimetic oxidation was used for the identification of nitric oxide (NO) donors with diverse chemical structure. Methodology was validated by testing known NO donors. Efficient automation of the test allowed us to investigate a subset of our corporate library. Several hits identified in this campaign were validated in both the… CONTINUE READING