Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.

@article{Sultana2006IdentificationON,
  title={Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.},
  author={Rukhsana Sultana and Hung Fai Poon and Jian Cai and William M. Pierce and Michael Merchant and Jon B. Klein and William R. Markesbery and David Butterfield},
  journal={Neurobiology of disease},
  year={2006},
  volume={22 1},
  pages={76-87}
}
Nitric oxide (NO) has been implicated in the pathophysiology of a number of neurodegenerative diseases including Alzheimer's disease (AD). In the present study, using a proteomics approach, we identified enolase, glyceraldehyde-3-phosphate dehydrogenase, ATP synthase alpha chain, carbonic anhydrase-II, and voltage-dependent anion channel-protein as the targets of nitration in AD hippocampus, a region that shows a extensive deposition of amyloid beta-peptide, compared with the age-matched… CONTINUE READING
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