Identification of nine human-specific frameshift mutations by comparative analysis of the human and the chimpanzee genome sequences

@article{Hahn2005IdentificationON,
  title={Identification of nine human-specific frameshift mutations by comparative analysis of the human and the chimpanzee genome sequences},
  author={Y. Hahn and B. Lee},
  journal={Bioinformatics},
  year={2005},
  volume={21 Suppl 1},
  pages={
          i186-94
        }
}
  • Y. Hahn, B. Lee
  • Published 2005
  • Biology, Medicine, Computer Science
  • Bioinformatics
  • MOTIVATION The recent release of the draft sequence of the chimpanzee genome is an invaluable resource for finding genome-wide genetic differences that might explain phenotypic differences between humans and chimpanzees. AVAILABILITY In this paper, we describe a simple procedure to identify potential human-specific frameshift mutations that occurred after the divergence of human and chimpanzee. The procedure involves collecting human coding exons bearing insertions or deletions compared with… CONTINUE READING
    55 Citations
    Human-specific nonsense mutations identified by genome sequence comparisons
    • 34
    • PDF
    An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence
    • GongXin Yu
    • Biology, Medicine
    • Comparative and functional genomics
    • 2009
    • 2
    • PDF
    Identification of human-specific transcript variants induced by DNA insertions in the human genome
    • 28
    • PDF
    Genome-wide analysis of chimpanzee genes with premature termination codons
    • 12
    Frequent appearance of novel protein-coding sequences by frameshift translation.
    • 51
    • PDF
    Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage
    • 102
    • PDF
    Gene Losses during Human Origins
    • 207
    • PDF

    References

    SHOWING 1-10 OF 37 REFERENCES
    DNA sequence and comparative analysis of chimpanzee chromosome 22
    • 223
    • PDF
    Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution
    • 262
    • PDF
    Genetic differences between humans and great apes.
    • 147
    • PDF
    Finishing the euchromatic sequence of the human genome
    • 1,534
    • PDF
    Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
    • 146
    • PDF
    Molecular evolution of FOXP2, a gene involved in speech and language
    • 1,259
    • PDF
    Human-specific duplication and mosaic transcripts: the recent paralogous structure of chromosome 22.
    • 169
    • PDF