Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.

@article{Galeazzi2011IdentificationON,
  title={Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.},
  author={Luca Galeazzi and Paola Bocci and Adolfo Amici and Lucia Brunetti and Silverio Ruggieri and Margaret R Romine and Samantha B. Reed and Andrei L. Osterman and Dmitry A. Rodionov and Leonardo Sorci and Nadia Raffaelli},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 46},
  pages={40365-75}
}
The pyridine nucleotide cycle is a network of salvage and recycling routes maintaining homeostasis of NAD(P) cofactor pool in the cell. Nicotinamide mononucleotide (NMN) deamidase (EC 3.5.1.42), one of the key enzymes of the bacterial pyridine nucleotide cycle, was originally described in Enterobacteria, but the corresponding gene eluded identification for over 30 years. A genomics-based reconstruction of NAD metabolism across hundreds of bacterial species suggested that NMN deamidase reaction… CONTINUE READING

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