Identification of new regulatory sequences far upstream of the mouse monocyte chemoattractant protein-1 gene.

@article{Wagner2001IdentificationON,
  title={Identification of new regulatory sequences far upstream of the mouse monocyte chemoattractant protein-1 gene.},
  author={K Wagner and Ulrich Dendorfer and Silvia Chilla and Detlef Schloendorff and Bruno Luckow},
  journal={Genomics},
  year={2001},
  volume={78 3},
  pages={113-23}
}
We systematically searched for sequences influencing the expression of the mouse monocyte chemoattractant protein-1 (MCP-1) gene (Scya2) by mapping DNase I hypersensitive sites (HS) in the chromatin of mesangial cells in a 40-kb interval around the gene. We found nine HS located between -24 kb and +12.7 kb. Three HS coincided with previously known regulatory sequences (HS-2.4, HS-1.0, and HS-0.2). We tested two of the previously unknown HS located far upstream of Scya2 (HS-19.4 and HS-16.3) in… CONTINUE READING