Identification of new possible targets for leukemia treatment by kinase activity profiling.

@article{Elst2011IdentificationON,
  title={Identification of new possible targets for leukemia treatment by kinase activity profiling.},
  author={Arja ter Elst and Sander Henricus Diks and K. R. van Kampen and Peter M. Hoogerbrugge and Rob Ruijtenbeek and Piet J. Boender and Arend H Sikkema and Frank J. G. Scherpen and Willem A. Kamps and Maikel P Peppelenbosch and Eveline S. J. M. de Bont},
  journal={Leukemia & lymphoma},
  year={2011},
  volume={52 1},
  pages={122-30}
}
To date, the biology of acute leukemia has been unclear, and defining new therapeutic targets without prior knowledge remains complicated. The use of high-throughput techniques would enable us to learn more about the biology of the disease, and make it possible to directly assess a broader range of therapeutic targets. In this study we have identified comprehensive tyrosine kinase activity profiles in leukemia samples using the PamChip® kinase activity profiling system. Strikingly, 31% (44/120… CONTINUE READING