Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance.

@article{Li2011IdentificationON,
  title={Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance.},
  author={Xin-hua Li and Feijun Luo and Qian Li and Mei-hua Xu and Deyun Feng and Gui-ying Zhang and Wei Wu},
  journal={Oncology reports},
  year={2011},
  volume={26 6},
  pages={
          1431-9
        }
}
miRNAs are small 19 to 22 nucleotide sequences of RNA that negatively regulate gene expression. miRNA expression profiles may become useful biomarkers for diagnostics, prognosis and prediction of response to treat, and it could be a powerful tool for cancer prevention and therapeutics. Several miRNA expression profiles of miRNAs in gastric cancer have been reported, but these studies screened only few miRNAs and samples used in… 
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Identification of Aberrantly Expressed miRNAs in Gastric Cancer
TLDR
A miRNA profile of gastric cancer is reported and new perspective to understand this malignant disease is provided to suggest the potential roles of these miRNAs in the diagnosis, prognosis biomarkers, or therapy targets of Gastric cancer.
MiRNA as potential biomarkers and therapeutic targets for gastric cancer.
TLDR
The up-to-date findings on the deregulated miRNAs in gastric cancer, and the potential use of miRNA in the clinical settings, such as diagnostic/prognostic markers and chemotherapeutic tools are highlighted.
Association of miR-193b down-regulation and miR-196a up-regulation with clinicopathological features and prognosis in gastric cancer.
TLDR
To investigate the hypothesis that genome-wide alternations of miRNAs differentiate gastric cancer tissues from those matched adjacent non-tumor tissues (ANTTs), miRNA arrays were employed to examine miRNA expression profiles for the 5-pair discovery stage, and the quantitative real-time polymerase chain reaction (qRT- PCR) was applied to validate candidate mi RNAs for 48-pair validation stage.
Analysis of Deregulated microRNAs and Their Target Genes in Gastric Cancer
Background MicroRNAs (miRNAs) are widely studied non-coding RNAs that modulate gene expression. MiRNAs are deregulated in different tumors including gastric cancer (GC) and have potential diagnostic…
Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis
TLDR
Various miRNAs are differentially expressed in gastric cancer and some of them could be further evaluated as biomarkers for early diagnosis of gastriccancer and prediction of prognosis or treatment response.
Evaluation of altered expression of miR-9 and miR-106a as an early diagnostic approach in gastric cancer.
TLDR
The results showed that the expression rate of both markers was significantly increased in cancerous tissues, and can be suggested as potential biomarkers for cancer diagnosis and prognosis as well as targets for therapy.
Current Status of MicroRNA-Based Biomarkers for Gastric Cancer
TLDR
The current knowledge about microRNA markers and their applicability in the diagnosis, prognosis, and prediction of treatment response in gastric cancer is summarized.
Gastric Cancer MicroRNAs Meta-signature.
TLDR
It is shown that hsa-miR-21-5p, hSA-mi R-93-5 p, hsa -mi-R-25-3p, and h sa-mi-375 are differentially expressed in GC samples, which is significantly different from previous studies.
The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
TLDR
Clinical significance and bioinformatic analysis on the target genes of these 4 miRNAs indicated that they were deeply involved in tumorigenesis, suggesting roles such as miRNA tumor suppressors in gastric cancer tumorigenisation which could be applied in gastrics cancer diagnosis and prognosis.
Evaluation of miR-22 and miR-20a as diagnostic biomarkers for gastric cancer.
TLDR
The obtained results suggestmiR-22 and miR-20a as good diagnostic biomarkers for early detection of GC, however more research is needed to investigate their efficacy.
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