Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

Abstract

Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non–small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8–3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.

DOI: 10.1038/nm.2673

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@article{Lipson2012IdentificationON, title={Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies}, author={Doron Lipson and Marzia Capelletti and R. Yelensky and Geoff A. Otto and Alex N. Parker and M. E. Jarosz and John A. Curran and Sohail Balasubramanian and Troy Bloom and Kristina W Brennan and Amy L Donahue and Sean R. Downing and Garrett M. Frampton and L{\'a}zaro Claudiovino Garcia and Frank S. Juhn and Kathy Mitchell and Emily White and Jared White and Zac Zwirko and Tamar Peretz and Hovav Nechushtan and Lior Soussan-Gutman and J . - Y . Kim and H. Sasaki and Hyeong Ryul Kim and Seung-Il Park and Dalia Ercan and Christine E. Sheehan and Jeffrey S Ross and Maureen T. Cronin and Pasi Antero J{\"a}nne and P. Stephens}, journal={Nature Medicine}, year={2012}, volume={18}, pages={382-384} }