Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.

@article{Mishra2003IdentificationON,
  title={Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.},
  author={Jaya Mishra and Qing Ma and Anne Prada and Mark M. Mitsnefes and Kamyar Zahedi and Jun Yang and Jonathan Barasch and Prasad Devarajan},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 10},
  pages={
          2534-43
        }
}
Acute renal failure (ARF) secondary to ischemic injury remains a common and potentially devastating problem. A transcriptome-wide interrogation strategy was used to identify renal genes that are induced very early after renal ischemia, whose protein products might serve as novel biomarkers for ARF. Seven genes that are upregulated >10-fold were identified, one of which (Cyr61) has recently been reported to be induced after renal ischemia. Unexpectedly, the induction of the other six transcripts… CONTINUE READING
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