Identification of naturally occurring amino acid variations that affect the ability of the measles virus C protein to regulate genome replication and transcription.

@article{Bankamp2005IdentificationON,
  title={Identification of naturally occurring amino acid variations that affect the ability of the measles virus C protein to regulate genome replication and transcription.},
  author={Bettina Bankamp and Jenna L Wilson and William J. Bellini and Paul A Rota},
  journal={Virology},
  year={2005},
  volume={336 1},
  pages={120-9}
}
The C protein of measles virus (MV C) is a basic protein of 186 amino acids (aa) that plays at least two roles in infected cells, interference with the innate immune response and modulation of viral polymerase activity. In this study, Northern blots were used to demonstrate that C proteins from three vaccine strains and three wild-type isolates of MV downregulated both mRNA transcription and genome replication in a plasmid-based mini-genome assay. The effect on transcription always paralleled… CONTINUE READING

From This Paper

Topics from this paper.
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…