Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.

  title={Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.},
  author={Ho-man Lee and Daniel Shiu-Hin Chan and Fang Yang and Ho-Yu Lam and Siu-cheong Yan and Chi‐Ming Che and Dik‐Lung Ma and Chung‐Hang Leung},
  journal={Chemical communications},
  volume={46 26},
Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure. 

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