Identification of myocardial and vascular precursor cells in human and mouse epicardium.

  title={Identification of myocardial and vascular precursor cells in human and mouse epicardium.},
  author={Federica Limana and Antonella Zacheo and David Mocini and Antonella Mangoni and Giovanna Borsellino and Adamo Diamantini and Roberta De Mori and Luca Battistini and Elisa Vigna and Massimo Santini and Vincenzo Loiaconi and Giulio Pompilio and Antonia Germani and Maurizio Colognesi Capogrossi},
  journal={Circulation research},
  volume={101 12},
During cardiac development, the epicardium is the source of multipotent mesenchymal cells, which give rise to endothelial and smooth muscle cells in coronary vessels and also, possibly, to cardiomyocytes. The aim of the present study was to determine whether stem cells are retained in the adult human and murine epicardium and to investigate the regenerative potential of these cells following acute myocardial infarction. We show that c-kit(+) and CD34(+) cells can indeed be detected in human… CONTINUE READING


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