Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: use in safer propagation of a novel vaccine candidate.

@article{Suzuki2008IdentificationOM,
  title={Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: use in safer propagation of a novel vaccine candidate.},
  author={Ryosuke Suzuki and Rafik Fayzulin and Ilya Frolov and Peter W. Mason},
  journal={Journal of virology},
  year={2008},
  volume={82 14},
  pages={6942-51}
}
Existing live-attenuated flavivirus vaccines (LAV) could be improved by reducing their potential to recombine with naturally circulating viruses in the field. Since the highly conserved cyclization sequences (CS) found in the termini of flavivirus genomes must be complementary to each other to support genome replication, we set out to identify paired mutant CS that could support the efficient replication of LAV but would be unable to support replication in recombinant viruses harboring one wild… CONTINUE READING
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Construction of an infectious cDNA clone for a Brazilian prototype strain of dengue virus type 1: characterization of a temperature-sensitive mutation in NS1

  • R. Suzuki, L. de Borba, C. N. Duarte dos Santos, P. W. Mason
  • Virology
  • 2007

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