Identification of multipotent cytotrophoblast cells from human first trimester chorionic villi.

@article{Spitalieri2009IdentificationOM,
  title={Identification of multipotent cytotrophoblast cells from human first trimester chorionic villi.},
  author={Paola Spitalieri and Giancarlo Cortese and Adalgisa Pietropolli and Antonio Filareto and Susanna Dolci and Francesca Gioia Klinger and Emiliano Giardina and Silvia Di Cesare and Laura Bernardini and Davide Lauro and Maria Lucia Scaldaferri and Gennaro Citro and Giuseppe Novelli and Massimo De Felici and Federica Sangiuolo},
  journal={Cloning and stem cells},
  year={2009},
  volume={11 4},
  pages={535-56}
}
In this article we used immunohistochemistry and FACS analyses to show that cells expressing markers typical of human stem cells such as SSEA4, OCT-4, ALP, and CD117 are present within the cytotrophoblastic tissue of human fetal chorionic villus samples (CVSs). After immunoselection of CV cells for SSEA4, FACS analyses showed an increased number of cells positive for OCT-4 and ALP and a small percentage (around 4%) of side population (SP) cells. In the same cell population, RT-PCR indicated the… CONTINUE READING

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