Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice

@article{Fujihara2019IdentificationOM,
  title={Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice},
  author={Y. Fujihara and T. Noda and K. Kobayashi and Asami Oji and Sumire Kobayashi and T. Matsumura and Tamara Larasati and Seiya Oura and Kanako Kojima-Kita and Z. Yu and M. Matzuk and M. Ikawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2019},
  volume={116},
  pages={18498 - 18506}
}
  • Y. Fujihara, T. Noda, +9 authors M. Ikawa
  • Published 2019
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Significance While the emergence of gene modification technologies has produced major discoveries in biomedical sciences, the recent development of the CRISPR/Cas9 system has dramatically altered the trajectory of phenotypic analysis in animal models. In this study, we identified male-specific gene clusters (Cst and Pate) and family genes (Gdpd and Lypd) and found specific members to be required for male fertility, especially for sperm fertilizing ability. Our findings support the important… Expand
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