Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease

  title={Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease},
  author={Travis Hughes and Patrick Coit and Adam J. Adler and Vuslat Yilmaz and Kenan Aksu and Nurşen D{\"u}zg{\"u}n and Gokhan Keser and Ayse Cefle and Ayten Yazici and Andaç Ergen and Erkan Alpsoy and Carlo Salvarani and Bruno Casali and Ina Koetter and Javier Guti{\'e}rrez-Achury and Cisca Wijmenga and Haner Direskeneli and G Saruhan-Direskeneli and Amr H. Sawalha},
  journal={Nature Genetics},
Behçet's disease is an inflammatory disease characterized by recurrent oral and genital ulcers and significant organ involvement. Localizing the genetic association between HLA-B*51 and Behçet's disease and exploring additional susceptibility loci in the human leukocyte antigen (HLA) region are complicated by the strong linkage disequilibrium in this region. We genotyped 8,572 variants in the extended HLA locus and carried out imputation and meta-analysis of 24,834 variants in 2 independent Beh… CONTINUE READING
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Genome - wide association studies identify IL 23 R - IL 12 RB 2 and IL 10 as Behçet ’ s disease susceptibility loci

  • N. Mizuki
  • Nat . Genet .
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Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet’s disease susceptibility

  • N Mizuki
  • loci. Nat. Genet
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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet’s disease

  • Remmers, E.F
  • Nat. Genet
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