Identification of multiple genetic susceptibility loci in Takayasu arteritis.

  title={Identification of multiple genetic susceptibility loci in Takayasu arteritis.},
  author={G Saruhan-Direskeneli and Travis Hughes and Kenan Aksu and Gokhan Keser and Patrick Coit and Sibel Zehra Aydin and Fatma Alibaz-Oner and Sevil Kamalı and Murat Inanç and Simon Carette and Gary S. Hoffman and Servet Akar and Fatos Onen and Nurullah Akkoc and Nader Khalidi and Curry Koening and Omer Karadag and Sedat Kiraz and Carol A Langford and Carol A McAlear and Zeynep Ozbalkan and Aşkin Ateş and Yasar Karaaslan and Kathleen M Maksimowicz-McKinnon and Paul Monach and H{\"u}seyin T E Ozer and Emire Seyahi and Izzet Fresko and Ayse Cefle and Philip Seo and Kenneth J. Warrington and Mehmet A. Ozturk and Steven Ytterberg and Veli Çobankara and Ahmet Mesut Onat and Joel M. Guthridge and Judith A James and Ercan Tunç and Nurşen Duzgun and Muge Bıcakcıgil and Sibel P. Yent{\"u}r and Peter A. Merkel and Haner Direskeneli and Amr H. Sawalha},
  journal={American journal of human genetics},
  volume={93 2},
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. We genotyped ~200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip). Additional genetic variants and the classical HLA alleles were imputed and… CONTINUE READING
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