Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC-DAD-MS/MS.

@article{Wang2011IdentificationOM,
  title={Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC-DAD-MS/MS.},
  author={Yan-Hui Wang and Cong Qiu and Dawei Wang and Zheng-fang Hu and Boyang Yu and Dan-ni Zhu},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2011},
  volume={54 5},
  pages={1110-27}
}
Sheng-Mai San (SMS), a traditional Chinese medicine formula, has been used for the treatment of cardiovascular disease in Asia over long period of time. While its effectiveness has been confirmed by clinical use, its active chemical constituents remain unclear. In this paper, an HPLC-DAD-MS/MS method is described for the efficient and rapid identification of the chemical constituents in SMS extract. MS/MS fragmentation behavior of authentic compounds was proposed for aiding the structural… CONTINUE READING

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