Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides.

@article{Ebner1993IdentificationOM,
  title={Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides.},
  author={Christof Ebner and Zsolt Sz{\'e}pfalusi and F{\'a}tima Ferreira and Alexander Jilek and Rudolf Valenta and Paola Parronchi and Enrico Maggi and Sergio Romagnani and Otto Scheiner and Dietrich Kraft},
  journal={Journal of immunology},
  year={1993},
  volume={150 3},
  pages={1047-54}
}
Eleven T cell clones (TCC) with specificity for Bet v I were established from the peripheral blood of six birch pollen allergic donors. Bet v I is the major allergen of birch (Betula verrucosa) pollen and shows high homology to the major allergens of pollens of other trees within the order fagales (hazel, alder, hornbeam, oak, etc.), which represent important inhalant allergens in the northern hemisphere. The TCC were shown to react with purified natural, as well as with purified recombinant… CONTINUE READING