Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3.

@article{Kim2000IdentificationOM,
  title={Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3.},
  author={J E Kim and Sang Jick Kim and Byron H. Lee and Rang Woon Park and Key Sun Kim and Il Shin Kim},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 40},
  pages={30907-15}
}
betaig-h3 is a transforming growth factor-beta-inducible cell adhesion molecule that has four characteristic homologous repeated domains. We made recombinant betaig-h3 proteins, which were highly active in mediating human corneal epithelial (HCE) cell adhesion and spreading. The 2nd and the 4th repeated domains were sufficient to mediate HCE cell adhesion. A sequence analysis showed that aspartic acid (Asp) and isoleucine (Ile) of the 2nd and the 4th domains are highly conserved in many… CONTINUE READING
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