Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919)

@article{Post2004IdentificationOM,
  title={Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919)},
  author={Anke Post and Frauke Ohl and Osborne F X Almeida and Elisabeth B. Binder and Monika R{\"u}cker and Sandra Welt and Elke Binder and Florian Holsboer and Inge Sillaber},
  journal={Psychopharmacology},
  year={2004},
  volume={180},
  pages={150-158}
}
The neuropeptide corticotropin-releasing hormone (CRH) plays a central role in the regulation of the hypothalamo–pituitary–adrenocortical (HPA) axis. The view that CRH hypersecretion underlies anxiety and mood disorders was recently supported by preclinical and clinical data obtained after application of the CRH receptor (CRH-R1) antagonist NBI30775 (R121919). Despite its therapeutic efficacy, there is only little information about its mechanisms of action on cellular and molecular targets. To… CONTINUE READING