Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays.

@article{Dong2002IdentificationOM,
  title={Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays.},
  author={Yan Mei Dong and Howard E. Ganther and Carleton Stewart and Clement Ip},
  journal={Cancer research},
  year={2002},
  volume={62 3},
  pages={708-14}
}
Past research indicated that methylseleninic acid (MSA) is an excellent tool for investigating the cancer chemopreventive action of selenium in vitro. The present study was designed to examine the cellular and molecular effects of MSA in the MCF10AT1 and MCF10AT3B premalignant human breast cells. After exposure to MSA, both cell lines exhibited a dose- and time-dependent growth-inhibitory response as determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell… CONTINUE READING
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