Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.

@article{Lei2013IdentificationOM,
  title={Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.},
  author={Zhengdeng Lei and Iain Beehuat Tan and Kakoli Das and Niantao Deng and Hermioni Zouridis and Sharon Pattison and Clarinda Wei Ling Chua and Zhu Xue Feng and Yeoh Khay Guan and Chia Huey Ooi and Tatiana Ivanova and Shenli Zhang and Minghui Lee and Jeanie Wu and Anna Ngo and Sravanthy Manesh and Elisabeth Tan and Bin Tean Teh and Jimmy Bok-Yan So and Liang Kee Goh and Alex Boussioutas and Tony Kiat Hon Lim and Horst Flotow and Patrick Y. Tan and Steven G Rozen},
  journal={Gastroenterology},
  year={2013},
  volume={145 3},
  pages={554-65}
}
BACKGROUND & AIMS Almost all gastric cancers are adenocarcinomas, which have considerable heterogeneity among patients. We sought to identify subtypes of gastric adenocarcinomas with particular biological properties and responses to chemotherapy and targeted agents. METHODS We compared gene expression patterns among 248 gastric tumors; using a robust method of unsupervised clustering, consensus hierarchical clustering with iterative feature selection, we identified 3 major subtypes. We… CONTINUE READING
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Intrinsic subtypesof gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy

  • IB Tan, IvanovaT, LimKH
  • Gastroenterology 2011;141:476–485
  • 2011
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