Identification of molecular subtypes of glioblastoma by gene expression profiling

@article{Mischel2003IdentificationOM,
  title={Identification of molecular subtypes of glioblastoma by gene expression profiling},
  author={Paul Mischel and Ruty Mehrian Shai and Tao Shi and Steve Horvath and Kan V. Lu and Gheeyoung Choe and David Seligson and Thomas J. Kremen and Aarno V Palotie and L M Liau and Timothy F. Cloughesy and Stanley F. Nelson},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={2361-2373}
}
Epidermal growth factor receptor (EGFR) overexpression occurs in nearly 50% of cases of glioblastoma (GBM), but its clinical and biological implications are not well understood. We have used Affymetrix high-density oligonucleotide arrays to demonstrate that EGFR-overexpressing GBMs (EGFR+) have a distinct global gene transcriptional profile. We show that… CONTINUE READING