Identification of molecular signature of head and neck cancer stem-like cells

  title={Identification of molecular signature of head and neck cancer stem-like cells},
  author={Shubham Shrivastava and Robert David Steele and Melanie Sowadski and Susan E Crawford and Mark Varvares and Ratna B Ray},
  booktitle={Scientific reports},
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer in the world. HNSCC remains difficult to treat, and despite advances in treatment, overall survival rate has modestly improved over the past several years. Poor survival rate is attributed to high frequency of local recurrence and distant metastasis. Cancer stem-like cells (CSCs) have been implicated in tumor recurrence and confer resistance to anti-cancer therapy treatment. In this study, we have characterized… CONTINUE READING
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