Identification of modulators of hair cell regeneration in the zebrafish lateral line.

@article{Namdaran2012IdentificationOM,
  title={Identification of modulators of hair cell regeneration in the zebrafish lateral line.},
  author={Parhum Namdaran and Katherine E. Reinhart and Kelly N. Owens and David W. Raible and Edwin W. Rubel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 10},
  pages={3516-28}
}
The external location of the zebrafish lateral line makes it a powerful model for studying mechanosensory hair cell regeneration. We have developed a chemical screen to identify FDA-approved drugs and biologically active compounds that modulate hair cell regeneration in zebrafish. Of the 1680 compounds evaluated, we identified two enhancers and six inhibitors of regeneration. The two enhancers, dexamethasone and prednisolone, are synthetic glucocorticoids that potentiated hair cell numbers… CONTINUE READING