Identification of minority resistance mutations in the HIV-1 integrase coding region using next generation sequencing.

Abstract

BACKGROUND The current widely applied standard method to screen for HIV-1 genotypic resistance is based on Sanger population sequencing (Sseq), which does not allow for the identification of minority variants (MVs) below the limit of detection for the Sseq-method in patients receiving integrase strand-transfer inhibitors (INSTI). Next generation sequencing… (More)
DOI: 10.1016/j.jcv.2015.11.009

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