Identification of miRNAs contributing to neuroblastoma chemoresistance

  title={Identification of miRNAs contributing to neuroblastoma chemoresistance},
  author={Duncan Ayers and Pieter Mestdagh and Tom M A Van Maerken and Jo Vandesompele},
  booktitle={Computational and structural biotechnology journal},
BACKGROUND The emergence of the role of microRNAs (miRNAs) in exacerbating drug resistance of tumours is recently being highlighted as a crucial research field for future clinical management of drug resistant tumours. The purpose of this study was to identify dys-regulations in expression of individual and/or networks of miRNAs that may have direct effect on neuroblastoma (NB) drug resistance. METHODS Individual subcultures of chemosensitive SH-SY5Y and UKF-NB-3 cells were rendered… CONTINUE READING
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