Identification of miRNA modulators to PARP inhibitor response.

  title={Identification of miRNA modulators to PARP inhibitor response.},
  author={Sari Neijenhuis and Ilirjana Bajrami and Rowan Miller and Christopher J Lord and Alan Ashworth},
  journal={DNA repair},
  volume={12 6},
Based on the principle of synthetic lethality, PARP inhibitors have been shown to be very effective in killing cells deficient in homologous recombination (HR), such as those bearing mutations in BRCA1/2. However, questions regarding their wider use persist and other determinants of responsiveness to PARP inhibitor remain to be fully explored. MicroRNAs (miRNAs) are small non-coding RNAs, which serve as post-transcriptional regulators of gene expression and are involved in a wide variety of… CONTINUE READING


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