Identification of miRNA modulators to PARP inhibitor response.

@article{Neijenhuis2013IdentificationOM,
  title={Identification of miRNA modulators to PARP inhibitor response.},
  author={Sari Neijenhuis and Ilirjana Bajrami and Rowan Miller and Christopher J Lord and Alan Ashworth},
  journal={DNA repair},
  year={2013},
  volume={12 6},
  pages={394-402}
}
Based on the principle of synthetic lethality, PARP inhibitors have been shown to be very effective in killing cells deficient in homologous recombination (HR), such as those bearing mutations in BRCA1/2. However, questions regarding their wider use persist and other determinants of responsiveness to PARP inhibitor remain to be fully explored. MicroRNAs (miRNAs) are small non-coding RNAs, which serve as post-transcriptional regulators of gene expression and are involved in a wide variety of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Reverse the Resistance to PARP Inhibitors

International journal of biological sciences • 2017
View 1 Excerpt

MicroRNAs, DNA Damage Response, and Cancer Treatment

International journal of molecular sciences • 2016
View 2 Excerpts

A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2015

Similar Papers

Loading similar papers…