Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44

@inproceedings{Liu2011IdentificationOM,
  title={Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44},
  author={Can Liu and Kevin Kelnar and Bigang Liu and Xin Mao Chen and Tammy Calhoun-Davis and Hangwen Li and Lubna Patrawala and Hong Yan and Collene R. Jeter and Sofia Honorio and Jason F. Wiggins and Andreas Bader and Randy Fagin and David Benjamin Brown and Dean G Tang},
  booktitle={Nature Medicine},
  year={2011}
}
Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and dysregulation of miRNAs has been implicated in tumorigenesis. CSCs in many tumors—including cancers of the breast, pancreas, head and neck, colon, small intestine, liver, stomach, bladder and ovary—have been identified using the adhesion molecule CD44, either individually or in combination with other marker(s). Prostate CSCs with… CONTINUE READING

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