Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

  title={Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype},
  author={Daniel T. Starczynowski and Florian Kuchenbauer and Bob Argiropoulos and Sandy Sung and Ryan D. Morin and Andrew L Muranyi and Martin Hirst and Donna Hogge and Marco La Marra and Richard A. Wells and Rena Buckstein and Wan L. Lam and Richard Keith Humphries and Aly Karsan},
  journal={Nature Medicine},
5q– syndrome is a subtype of myelodysplastic syndrome characterized by severe anemia and variable neutropenia but normal or high platelet counts with dysplastic megakaryocytes. We examined expression of microRNAs (miRNAs) encoded on chromosome 5q as a possible cause of haploinsufficiency. We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll–interleukin-1 receptor… CONTINUE READING
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Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays

  • L Wang
  • Haematologica 93,
  • 2008

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