Identification of metastasis-related microRNAs in hepatocellular carcinoma.

@article{Budhu2008IdentificationOM,
  title={Identification of metastasis-related microRNAs in hepatocellular carcinoma.},
  author={Anuradha S. Budhu and Hu-Liang Jia and Marshonna Forgues and Chang-gong Liu and David Goldstein and Amy R. Lam and Krista A. Zanetti and Qing-hai Ye and Lunxiu Qin and Carlo M Croce and Zhao-you Tang and Xin Wei Wang},
  journal={Hepatology},
  year={2008},
  volume={47 3},
  pages={
          897-907
        }
}
MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131… CONTINUE READING
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