• Corpus ID: 12693663

Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans.

@article{Callery1986IdentificationOM,
  title={Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans.},
  author={Patrick S. Callery and Merrill J. Egorin and Linda A. Geelhaar and M. S. Balachandran Nayar},
  journal={Cancer research},
  year={1986},
  volume={46 10},
  pages={
          4900-3
        }
}
Hexamethylene bisacetamide, a compound which in vitro induces differentiation in a wide variety of human and animal cancer cell lines, is being investigated in phase I clinical trials. After i.v. administration of hexamethylene bisacetamide to humans, urine contained the parent compound and at least five metabolites formed by deacetylation and oxidation pathways. Identification of urinary metabolites was accomplished by gas chromatography-mass spectrometric analysis after isolation by ion… 

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