Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine.

  title={Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine.},
  author={Sudarsanan Varaprath and Kevin L. Salyers and Kathleen P Plotzke and Sachin Nanavati},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={27 11},
Octamethylcyclotetrasiloxane (D(4)) is an industrial chemical of significant commercial importance. In this study, its major urinary metabolites were identified. The urine samples described here were collected from male and female Fischer rats (F-344) administered [(14)C]D(4) i.v. The metabolite profile was obtained using an HPLC system equipped with a radioisotope detector. HPLC analysis was performed on a C18 column, using an acetonitrile/water mobile phase. The HPLC radiochromatogram… CONTINUE READING


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