Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.

@article{Shu2010IdentificationOM,
  title={Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.},
  author={Xiao-hong Shu and Hong Li and Zheng Sun and Mo-li Wu and Jing-xin Ma and Jian-min Wang and Qian Wang and Yuan Sun and Yuan-Shan Fu and Xiaoyan Chen and Qing-you Kong and Jia Liu},
  journal={Biochemical pharmacology},
  year={2010},
  volume={79 10},
  pages={1516-25}
}
Cancer preventive reagent trans-resveratrol is intracellularly biotransformed to different metabolites. However, it is still unclear whether trans-resveratrol exerts its biological effects directly or through its metabolite(s). This issue was addressed here by identifying the metabolic pattern and the bioactive form of resveratrol in a resveratrol-sensitive human medulloblastoma cell line, UW228-3. The cell lysates and condition media of UW228-3 cells with or without 100 microM resveratrol… CONTINUE READING
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