Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.

@article{Dalmadi2003IdentificationOM,
  title={Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.},
  author={Bal{\'a}zs Dalmadi and J{\'a}nos Leibinger and Sz. Szeber{\'e}nyi and T{\'i}mea Borb{\'a}s and S{\'a}ndor Farkas and Zsolt Szombathelyi and Károly Tihanyi},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 5},
  pages={
          631-6
        }
}
The in vitro metabolism of tolperisone, 1-(4-methyl-phenyl)-2-methyl-3-(1-piperidino)-1-propanone-hydrochloride, a centrally acting muscle relaxant, was examined in human liver microsomes (HLM) and recombinant enzymes. Liquid chromatography-mass spectrometry measurements revealed methyl-hydroxylation (metabolite at m/z 261; M1) as the main metabolic route in HLM, however, metabolites of two mass units greater than the parent compound and the hydroxy-metabolite were also detected (m/z 247 and m… Expand
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