Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos.

@article{Wang2008IdentificationOM,
  title={Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos.},
  author={Xiao-yan Wang and Yu Lan and Wen-yan He and Lei Zhang and Hui-yu Yao and C. I. Hou and Ying Tong and Yuan-lin Liu and Guan Gen Yang and Xiao-Dan Liu and Xiao Yang and Bing Liu and Ning Mao},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={2436-43}
}
Mesenchymal stem cells (MSCs) are multipotent stem cells that can generate various microenvironment components in bone marrow, ensuring a precise control over self-renewal and multilineage differentiation of hematopoietic stem cells. Nevertheless, their spatiotemporal correlation with embryonic hematopoiesis remains rudimentary, particularly in relation to the human being. Here, we reported that human aorta-gonad-mesonephros (AGM) resided with bona fide MSCs. They were highly proliferative as… CONTINUE READING

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