Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers

@article{Takahashi2002IdentificationOM,
  title={Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers},
  author={Meiko Takahashi and Tatsuhiko Tsunoda and Motoharu Seiki and Yusuke Nakamura and Yoichi Furukawa},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5861-5867}
}
Genetic alterations of APC and CTNNB1 (β-catenin) have been identified in a number of human cancers including tumors arising in the colon and liver. Mutations in these genes lead to abnormal accumulation of β-catenin and constitutive activation of target genes in the Wnt signaling pathway. To clarify the precise role of accumulated β-catenin in colorectal carcinogenesis, we searched for genes involved in the β-catenin/Tcf signaling pathway by cDNA microarray. MT1–MMP (membrane-type matrix… CONTINUE READING
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