Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1).

@article{Bchner1999IdentificationOM,
  title={Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1).},
  author={Dietmar B{\"a}chner and H J Kreienkamp and Christoph Weise and Friedrich Buck and Diane E. Richter},
  journal={FEBS letters},
  year={1999},
  volume={457 3},
  pages={
          522-4
        }
}
To identify possible ligands of the orphan somatostatin-like receptor 1 (SLC-1), rat brain extracts were analyzed by using the functional expression system of Xenopus oocytes injected with cRNAs encoding SLC-1 and G protein-gated inwardly rectifying potassium channels (GIRK). A strong inward current was observed with crude rat brain extracts which upon further purification by cation exchange chromatography and high performance liquid chromatography (HPLC) yielded two peptides with a high… CONTINUE READING
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