Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.

@article{Bauer2010IdentificationOM,
  title={Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.},
  author={Joshua A Bauer and A. Bapsi Chakravarthy and Jennifer M Rosenbluth and Deming Mi and Erin H. Seeley and Nara De Matos Granja-Ingram and Mar{\'i}a Graciela Olivares and Mark C. Kelley and Ingrid A. Mayer and Ingrid M. Meszoely and Julie Means-Powell and Kimberly N. Johnson and Chiaojung Jillian Tsai and Gregory Daniel Ayers and Melinda E Sanders and Robert J Schneider and Silvia Chiara Formenti and Richard M Caprioli and Jennifer A. Pietenpol},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 2},
  pages={681-90}
}
PURPOSE To identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies. EXPERIMENTAL DESIGN Patients with high-risk, operable breast cancer were treated with three cycles of paclitaxel followed by concurrent paclitaxel/radiation. Tumor tissue from pretreatment biopsies was obtained from 19 of the 38 patients enrolled in the study. Protein and gene expression profiling were done on… CONTINUE READING
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